WebPY - 2006/2/1. Y1 - 2006/2/1. N2 - The tumor suppressor gene BRCA1 maintains genomic integrity by protecting cells from the deleterious effects of DNA double-strand breaks (DSBs). Through its interactions with the checkpoint kinase 2 (Chk2) kinase and Rad51, BRCA1 promotes homologous recombination, which is typically an error-free repair … WebAnother moderate risk breast cancer gene is CHEK2 (checkpoint kinase 2). CHEK2 encodes a cell cycle checkpoint kinase that plays an important role in the DNA damage …
Checkpoint kinase 2-mediated phosphorylation of BRCA1 …
WebOct 14, 2024 · Checkpoint Kinase 2 Tamoxifen RNA, Small Interfering Checkpoint Kinase 1 Ataxia Telangiectasia Mutated Proteins Grant support 07182026/Health and Medical Research Fund 07182046/Health and Medical Research Fund 17113020/Research Grants Council, Hong Kong General Research Fund ... WebChk2-IN-1 (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC50 s of 13.5 nM and 220.4 nM for Chk2 and Chk1, respectively. Chk2-IN-1 can elicit a strong ataxia telangiectasia mutated (ATM)-dependent Chk2-mediated radioprotection effect. HY-18958. CCT245737. Inhibitor. haughty manner
Gene Mutation CHEK2 and Cancer Risk Everyday Health
WebAnother moderate risk breast cancer gene is CHEK2 (checkpoint kinase 2). CHEK2 encodes a cell cycle checkpoint kinase that plays an important role in the DNA damage repair pathway. Several CHEK2 mutations are associated with increased breast cancer risk in Eastern and Northern European populations including the 1100delC mutation, the … CHEK2 (Checkpoint kinase 2) is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linked to a wide range of cancers. See more The CHEK2 gene is located on the long (q) arm of chromosome 22 at position 12.1. Its location on chromosome 22 stretches from base pair 28,687,742 to base pair 28,741,904. See more The CHEK2 protein encoded by the CHEK2 gene is a serine threonine kinase. The protein consists of 543 amino acids and the following See more The CHK2 protein plays a critical role in the DNA damage checkpoint. Thus, mutations to the CHEK2 gene have been labeled as causes to a wide range of cancers. See more CHEK2 has been shown to interact with: • BRCA1 • GINS2 • MDC1 • MSH2 • MUS81 • PLK1 See more The CHEK2 gene encodes for checkpoint kinase 2 (CHK2), a protein that acts a tumor suppressor. CHK2 regulates cell division, and has the ability to prevent cells from dividing too … See more CHEK2 regulates cell cycle progression and spindle assembly during mouse oocyte maturation and early embryo development. Although CHEK2 is … See more • Caspari T (April 2000). "How to activate p53". Current Biology. 10 (8): R315-7. doi:10.1016/S0960-9822(00)00439-5. PMID 10801407 See more WebCheckpoint kinase 2 (human CHEK2; murine Chk2) is a critical mediator of the DNA damage response and has established roles in DNA double strand break (DSB)-induced … haughty look